During an infection, the body naturally produces pro-inflammatory cytokines as part of its defense mechanism. The healthy body balances pro-inflammatory cytokines with anti-inflammatory cytokines. However, if pro-inflammatory cytokines such as IL-1, IL-6, IL-8, IL-17, IL-23, Tumor Necrosis Factor-alpha (TNF-α), or Nuclear Factor kappa Beta (NF-κß), continue in the “on position” after the immune threat has ended, inflammation levels remain high. Long-term or chronic inflammation can negatively impact overall health, contributing to chronic pain, poor sleep quality, and unhealthy cardiovascular function. Recent studies have demonstrated that maintaining healthy cytokine function is essential to healthful aging. 90 Capsules.